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An intensive and comprehensive
laboratory-oriented course in cellular and molecular neurobiology
intended for predoctoral students, postdoctoral or clinical
researchers, and young investigators beginning independent research
careers. Limited to 14 students.
A hallmark of this course is the extensive lab work done in close
collaboration with expert faculty. The course is divided into three
sections: Electrophysiology, Imaging, and Molecular Neurobiology. These
are taught by separate groups of faculty, usually six in each section,
and with many guest lecturers. Each section begins with specific
training in core laboratory techniques; students then undertake one- to
two-week directed or independent projects using the methods they have
learned. Didactic lectures are combined with laboratory experience in
order to establish a strong conceptual foundation for each section. A
typical day has 3 hours of lecture and 10 hours of lab.
Electrophysiological methods focus on patch-clamp and sharp electrode
recordings, performed on neurons in a variety of preparations,
including tissue culture, brain slices, isolated squid synapses, rat
cochlea, or whole fish. Optical methods include calcium imaging,
confocal and 2-photon microscopy, videomicroscopy, and electron
microscopy. Molecular techniques emphasize the use of forward and
reverse genetics in diverse systems such as Drosophila, C. elegans,
zebrafish,
chick
embryos,
and primary cells in culture. The impact of
genetic manipulations are assayed by real time PCR, laser
microdissection, single cell PCR, in situ hybridization, and a
variety of immunotechniques in addition to incorporating
electrophysiological and imaging techniques.
The goal of the course is to emphasize the strengths of a
multidisciplinary approach for studying the function of the nervous
system at the cellular and molecular levels.
This course is supported with funds provided by
National
Institute
of
Neurological
Disorders and Stroke, NIH
Howard
Hughes Medical Institute
The Grass Foundation
International Brain Research Organization
2011 Faculty and Lecturers
Carlos Aizenman, Brown University
Ricardo Araneda, University of
Maryland
Maureen Barr, Rutgers University
Diana Bautista, University of
California, Berkeley
Bruce Bean, Harvard Medical School
Linda Brzustowicz, Rutgers University
JoAnn Buchanan, Stanford University
Ingrid Bureau, INSERM
Ed Callaway, The Salk Institute
Andrew Chisholm, University of
California, San Diego
Kathryn Commons, Children's Hospital/Harvard Medical School
Matthew Dalva, University of Pennsylvania
Joseph DeGiorgis, Providence College
Elva Diaz, University of California, Davis
Michael Dickinson, California
Institute of Technology
Fiona Doetsch, Columbia University
Benjamin Eaton, University of Texas
Health Science Center
Catherine Galbraith, National
Institutes of Health
James Galbraith, National
Institutes
of Health
Michael Greenberg, Harvard Medical
School
Kristen Harris, University of Texas
at Austin
Daniel Johnston, University
of
Texas at Austin
Richard Kramer, University of
California, Berkeley
Jeff Lichtman, Harvard University
Isabel Llano, CNRS
Rodolfo Llinas, New York University
Medical Center
Roderick MacKinnon, The Rockefeller University, HHMI
Andres Maricq, University of Utah
Alain Marty, CNRS
Ed McCleskey, Howard Hughes Medical
Center
Kristina Micheva, Stanford University
Thomas Misgeld, Technical University Munich
Wade Regehr, Harvard Medical School
Edward Ruthazer, McGill University
Timothy Ryan, Weill Cornell Medical
College
Jon Sack, Protean Research
Joshua Sanes, Harvard University
Peter Scheiffele, Biozentrum University Basel
Stephen Smith, Stanford University
School of Medicine
David Speca, University of
California, Davis
Joshua Trachtenberg, University of
California, Los Angeles
James Trimmer, University of
California, Davis
Larry Trussell, Oregon Health & Science University
Monica Vetter, University of Utah
Philip Washbourne, University of Oregon
Ryohei Yasuda, Duke University Medical Center
Yi Zuo, University of California, Santa Cruz
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